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Home - Products - MAPK/ERK Signaling - Ras - pan-Ras inhibitor 3144

pan-Ras inhibitor 3144

CAS No. 1835283-94-7

pan-Ras inhibitor 3144( Compound 3144 )

Catalog No. M12834 CAS No. 1835283-94-7

pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    pan-Ras inhibitor 3144
  • Note
    Research use only, not for human use.
  • Brief Description
    pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor.
  • Description
    pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively; shows weak bindinf for RRAS2 (Kd=24 uM) and no activity for other small GTPases in the RAS superfamily; exhibits lethality in cells partially dependent on expression of RAS proteins; has suitable ADME properties and displays anti-tumor activity in xenograft mouse of pancreatic cancer; orally bioavailable.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Compound 3144
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1835283-94-7
  • Formula Weight
    717.659
  • Molecular Formula
    C36H41Cl2F3N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 50 mg/mL 69.67 mM
  • SMILES
    O=C(C1(N)CCNCC1)NCCCN2C=C(C3=CC=C(OC(F)(F)F)C=C3)C4=C2C=CC(CN5CCN(CC6=C(Cl)C=CC=C6Cl)CC5)=C4
  • Chemical Name
    4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Welsch ME, et al. Cell. 2017 Feb 23;168(5):878-889.e29.
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